Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

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Description

DOB Also known as:

  • 2,5-Dimethoxy-4-bromoamphetamine[Wiki]
  • (±)-1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane
  • (±)-1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane
  • (±)-2,5-Dimethoxy-4-bromoamphetamine
  • (±)-2,5-Dimethoxy-4-bromoamphetamine
  • (±)-4-Bromo-2,5-dimethoxy-α-methylphenethylamine
  • 1-(4-Brom-2,5-dimethoxyphenyl)-2-propanamin[German][ACD/IUPAC Name]
  • 1-(4-Bromo-2,5-dimethoxyphenyl)-2-propanamine[ACD/IUPAC Name]
  • 1-(4-Bromo-2,5-diméthoxyphényl)-2-propanamine[French][ACD/IUPAC Name]
  • 1-(4-Bromo-2,5-dimethoxyphenyl)propan-2-amine
  • 4-Bromo-2,5-dimethoxy-amphetamine
  • 5874
  • Benzeneethanamine, 4-bromo-2,5-dimethoxy-α-methyl-[ACD/Index Name]
  • Benzeneethanamine, 4-bromo-2,5-dimethoxy-α-methyl-, (±)-
  • brolamfétamine[French][INN]
  • BROLAMFETAMINE, (R)-
  • BROLAMFETAMINE, (S)-
  • Brolamfetaminum[Latin][INN]
  • brolamphetamine
  • brolanfetamina[Spanish][INN]
  • dl-2,5-Dimethoxy-4-bromoamphetamine
  • броламфетамин[Russian][INN]
  • برولامفيتامين[Arabic][INN]
  • 布苯丙胺[Chinese][INN]
  • (±)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine
  • (±)-2,5-Dimethoxy-4-bromoamphetamine
  • (±)-4-Bromo-2,5-dimethoxy-α-methylphenethylamine
  • [3H](+)DOB
  • 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane
  • 2-(2-Methoxy-Phenyl)-1-Methyl-Ethylamine
  • 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine
  • 2-(5-Bromo-2,4-dimethoxy-phenyl)-1-methyl-ethylamine
  • 2,5-dimethoxy-(4-bromo)phenylisopropylamine
  • 2,5-DIMETHOXY-4-BROMAMPHETAMIN
  • 2,5-DIMETHOXY-4-BROMAMPHETAMINE
  • 2,5-dimethoxy-4-bromoamphetamine|DOB
  • 2,5-DIMETHOXY-4-BROMOAMPHETAMINE-D6
  • 4-Bromo-2,5-dimethoxy-a-methylbenzeneethanamine
  • 4-Bromo-2,5-dimethoxyamphetamine
  • 4-bromo-2,5-dimethoxyphenylisopropylamine
  • 4-bromo-2,5-dimethoxyphenylisopropylaminerolamfetamine
  • 4-bromo-2,5-dimethoxy-α-methylbenzeneethanamine
  • 4-Bromo-DMA
  • Benzeneethanamine,4-bromo-2,5-dimethoxy-α-methyl-(±)-
  • DOB
  • DOB-4

DOB is a relatively uncommon synthetic psychedelic. It is best known for its very low doses and long duration. Historically it has rarely been taken deliberately, but in place of LSD, however it has recently found its own place in the research chemical scene.

Summary

It is a member of the DOx family of psychedelic amphetamines. While DOB had first been synthesized in 1967 and briefly tested in 1971, it took until the 1991 publication of the book PiHKAL ("Phenethylamines I Have Known And Loved") by Alexander Shulgin to be documented in-depth. Today, DOB is used as a recreational drug and an entheogen.

It is still rarely sold online but is more commonly found in the streets the form of misrepresented LSD due to its ability to fit onto similar-sized blotter paper. Very little data exists about the pharmacological properties, metabolism, and toxicity of DOB in humans. Along with its sensitive dose-response, unusually long and unpredictable duration, many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with using hallucinogens.

It is highly advised to use harm reduction practices if using this substance.

Chemistry

Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα.

DOB contains methoxy functional groups OCH3 attached to carbons R2 and R5 as well as a bromine atom attached to carbon R4 of the phenyl ring.

DOB is the amphetamine analogue of the phenethylamine 2C-B.

Common Name2,5-Dimethoxy-4-bromoamphetamine
Systematic name2,5-Dimethoxy-4-bromoamphetamine
FormulaC_{11}H_{16}BrNO_{2}
SMILESCC(Cc1cc(c(cc1OC)Br)OC)N
Std. InChiInChI=1S/C7H6O4/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,8-9H,(H,10,11)
Std. InChiKeyUIAFKZKHHVMJGS-UHFFFAOYSA-N
Avg. Mass274.1542 Da
Molecular Weight274.1542
Monoisotopic Mass273.036438 Da
Nominal Mass273
ChemSpider ID55902

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Dose Chart

Oral
Threshold500ug
Light750ug
Common750-1100ug
Heavy1100-1500ug
Dangerous3000ug

Duration Chart

DOB Duration Data
Onset30-120 minutes
Duration8-24 hours
After-effects2-12 hours

Interactions

Caution

  1. Mescaline
  2. NBOMes
  3. 2C-x
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. MXE
    • As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
  8. MDMA
    • The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
  9. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
  10. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably

Dangerous

  1. DXM
    • The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
  2. PCP
    • Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
  3. Amphetamines
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  4. Cocaine
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
  5. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Low Synergy

  1. Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Opioids
    • No unexpected interactions.

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
    • Ketamine and psychedelics tend to potentiate each other - go slowly.
  5. N2O

Legal Status

Internationally, DOB is a Schedule I drug under the Convention on Psychotropic Substances.

  • Australia: DOB is listed as a Schedule II substance in Australia.
  • Austria: DOB is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).
  • Canada: DOB is listed as a Schedule 1 as it is an analogue of amphetamine.
  • Germany: DOB is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of September 1, 1984. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Latvia: DOB is a Schedule I controlled substance.
  • New Zealand: DOB is Schedule I (Class A) in New Zealand. DOB would also qualify as an analogue under New Zealand's catch-all analogues section in Schedule 3 / Class C of their drug laws which would make 2C-I, 2C-E, DOI, DOB, ephedrine, and pseudoephedrine Schedule 3 compounds in the country.
  • Poland: DOB is controlled in Poland.
  • Switzerland: DOB is illegal in Switzerland.
  • United Kingdom: DOB is Schedule I/Class A in the U.K., making it illegal to sell, buy, or possess without a license.
  • United States: DOB is Schedule I in the U.S., making it illegal to sell, buy, gift, produce or possess without a DEA license.
  • Sources

    References

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    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

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