Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

Read the full disclaimer here.

Description

DMT Also known as:

  • (2-Indol-3-ylethyl)dimethylamine
  • 1H-Indole-3-ethanamine, N,N-dimethyl-[ACD/Index Name]
  • 2-(1H-Indol-3-yl)-N,N-dimethylethanamin[German][ACD/IUPAC Name]
  • 2-(1H-Indol-3-yl)-N,N-dimethylethanamine[ACD/IUPAC Name]
  • 2-(1H-Indol-3-yl)-N,N-diméthyléthanamine[French][ACD/IUPAC Name]
  • DMT
  • Indole, 3-(2-(dimethylamino)ethyl)-
  • Indole, 3-[2- (dimethylamino)ethyl]-
  • Indole, 3-[2-(dimethylamino)ethyl]-
  • MFCD00055989[MDL number]
  • N,N-Dimethyl-1H-indole-3-ethanamine
  • N,N-dimethyl-1H-indole-3-ethylamine
  • N,N-Dimethyltryptamine[Wiki]
  • N,N-DMT
  • tryptamine, dimethyl-
  • [2-(1H-Indol-3-yl)-ethyl]-dimethyl-
  • [2-(1H-indol-3-yl)ethyl]dimethylamine
  • [2-(1H-Indol-3-yl)-ethyl]-dimethyl-amine
  • 1H-INDOLE-3-ETHANAMINE,N,N-DIMETHYL
  • 1H-Indole-3-ethanamine,N,N-dimethyl-
  • 2-(1H-indol-3-yl)ethyl-dimethyl-amine
  • 2-(1H-indol-3-yl)-N,N-dimethyl-ethanamine
  • 2-(3-indolyl)ethyldimethylamine
  • 3-(2-(Dimethylamino)ethyl)-Indole
  • 3-(2-Dimethylaminoethyl) indole
  • 3-(2-dimethylaminoethyl)indole
  • 3-[2- (Dimethylamino)ethyl]-Indole
  • 3-[2-(dimethylamino)ethyl]indole
  • 5-22-10-00048 (Beilstein Handbook Reference)[Beilstein]
  • N N-DIMETHYL-1H-INDOLE-3-ETHYLAMINE
  • WLN: T56 BMJ D2N1&1

A popular and powerful psychedelic, typically used in two ways; either it is vapourised for a short ‘breakthrough’ experience, or it is taken in combination with an enzyme inhibitor for a long, intense trip (this is also known as ayahuasca or pharmahuasca).

Summary

Despite being one of the simplest psychedelic compounds, it is known for its unique ability to produce short-lived but intense visionary states and complete hallucinations. It is thought to produce its psychedelic effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood. DMT is present in over 65 species of plants and has been identified as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents.

Its presence is also known to be widespread throughout the plant kingdom. Although various theories have been postulated, its neurobiological function has yet to be determined. Depending on the dosage and method of administration, the effects of DMT can range from mild psychedelic states to powerfully immersive life-altering experiences which are often described as the ultimate displacement from ordinary consciousness in which users report experiencing ineffable spiritual realms or alternate dimensions.

When vaporized or smoked, DMT produces short-lived effects with a very rapid onset that is sometimes described as an “inconceivably high-speed rollercoaster ride. " When ingested in combination with a MAOI or RIMA agent, it becomes active orally and significantly longer lasting, immersive, and interactive in nature: this combination is known as ayahuasca. Ayahuasca brews have been used traditionally in South America since at least around the year 1500.

Unlike most highly prohibited substances, DMT is not considered to be addictive or toxic by the scientific community. Nevertheless, unpredictable adverse reactions such as uncontrollable anxiety, delusions and psychosis can always occur, particularly among those predisposed to mental disorders. While these negative reactions or “bad trips” can often be attributed to user inexperience or improper preparation of set and setting, they have been known to happen spontaneously among even highly experienced users as well.

It is therefore highly advised to use harm reduction practices if using this substance.

History

In 1955, a team of American chemists led by Evan Horning isolated and formally identified DMT in the seeds and pods of Anadenanthera peregrina. Since 1955, DMT has been found in a host of organisms: in at least fifty plant species belonging to ten families, and in at least four animal species, including one gorgonian and three mammalian species.

Chemistry

Tryptamines share a core structure consisting of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.

DMT contains two methyl groups (CH3-) bound to the terminal amine RN at the end of this chain. DMT has many homologs and analogs from base tryptamines like MET and DPT, to four and five position substituted variants such as 4-PO-DMT (psilocybin), 4-AcO-DMT (psilacetin), 5-HO-DMT (bufotenin), and 5-MeO-DMT. DMT is a white, pungent-smelling, crystalline solid.

It is insoluble in water, but soluble in organic solvents and aqueous acids.

Common NameDimethyltryptamine
Systematic nameDimethyltryptamine
FormulaC_{12}H_{16}N_{2}
SMILESCN(C)CCc1c[nH]c2c1cccc2
Std. InChiInChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3
Std. InChiKeyDMULVCHRPCFFGV-UHFFFAOYSA-N
Avg. Mass188.2688 Da
Molecular Weight188.2688
Monoisotopic Mass188.131348 Da
Nominal Mass188
ChemSpider ID5864

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Dose Chart

Vapourised
Threshold5-10mg
Light10-15mg
Common15-25mg
Strong25-35mg
Heavy35mg+
Insufflated
Light10-25mg
Common25-50mg
Strong50-125mg+
Intravenous
Light10-15mg
Common15-25mg
Strong25-40mg

Duration Chart

Vaporized/smoked
Onset0-2 minutes
Duration3-10 minutes
After-effects15-60 minutes

Interactions

Caution

  1. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  2. Amphetamines
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  3. Cocaine
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

Dangerous

  1. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Low Synergy

  1. Alcohol
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Caffeine
  2. Opioids

High Synergy

  1. Mushrooms
  2. LSD
  3. Mescaline
  4. DOx
  5. NBOMes
  6. 2C-x
  7. 2C-T-x
  8. αMT
  9. 5-MeO-xxT
  10. Ketamine
  11. MXE
  12. DXM
  13. PCP
  14. N2O
  15. MDMA
  16. MAOIs

Legal Status

Internationally, DMT is classified as a Schedule I controlled substance under the United Nations 1971 Convention on Psychotropic Substances, meaning that international trade in DMT is supposed to be closely monitored and its use is supposed to be restricted to scientific research and medical use. Natural materials containing DMT, including ayahuasca, are not regulated under the 1971 Psychotropic Convention.

  • Australia: DMT is controlled under Schedule 9 of the Poisions Standard.

  • Austria: DMT is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).
  • Brazil: DMT is illegal to possess, produce and sell under Portaria SVS/MS nº 344. Rules are relaxed regarding religious use.
  • Canada: DMT is a Schedule III controlled substance.
  • Denmark: DMT is a Category B controlled substance.
  • Estonia: DMT is a Schedule I controlled substance.
  • France: DMT is classified as a narcotic.
  • Germany: DMT is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of January 24, 1974. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Italy: DMT is a Schedule I controlled substance.
  • Hungary: DMT is illegal to possess, produce and sell.
  • Ireland: DMT is controlled under the Misuse of Drugs Acts, 1977.
  • Latvia: DMT is a Schedule I controlled substance.
  • The Netherlands: DMT is classified as a Lijst 1 (List I) controlled substance under the Opiumwet (Opium Law).
  • New Zealand: DMT is classified in New Zealand as a Class A controlled substance under the Misuse of Drugs Act 1975.
  • Norway: DMT is a Schedule I controlled substance.
  • Russia: DMT is a список I (List I) contolled substance. It is illegal to possess, produce and sell.
  • Serbia: DMT is a List 4 controlled substance.
  • Sweden: DMT is controlled under Förteckning I (Schedule 1).
  • United Kingdom: DMT is a Class A controlled substance.
  • United States: DMT is a Schedule I controlled substance. Rules are relaxed regarding religious use, however. In the US, dried root bark of Mimosa hostilis had been considered a "grey area" item for a long time. However, recent efforts by the DEA appear to be focusing on eliminating internet sales of the bark, citing 21 USC § 841, which states that "(IV) any compound, mixture, or preparation which contains any quantity of any of the substances referred to in subclauses (I) through (III)" is also considered an illegal substance. Many USA based vendors have since been stocking Acacia confusa bark as a result due to its very similar alkaloid content.

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    301. SynQuest 3H32-1-0R
    302. The Merck Index Online cs000000007449
    303. Thieme Chemistry SD-110-00020
    304. Thomson Pharma 00483902
    305. Thoreauchem TH-B00149
    306. Tocris Bioscience 3428
    307. Tractus Company Limited
    308. Urine Metabolome Database HMDB0005973
    309. VulcanChem VC009379
    310. Wikidata Q407217
    311. Wikipedia Dimethyltryptamine
    312. Wikipedia N,N-Dimethyltryptamine
    313. xPharm 9015
    314. ZINC ZINC00897457

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