Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

Read the full disclaimer here.

Description

Cannabis Also known as:

  • (-)-δ9-trans-Tetrahydrocannabinol
  • Δ9-Tetrahydrocannabinol
  • Δ9--THC
  • (-)-trans-δ9-Tetrahydrocannabinol
  • (-)-trans-δ9-THC
  • (-)-δ 9-Tetrahydrocannabinol
  • (-)-δ9-Tetrahydrocannabinol
  • (-)-δ9-Tetrahydrocannabinol
  • (-)-δ9-THC
  • (-)-δ9-trans-Tetrahydrocannabinol
  • (6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol[ACD/IUPAC Name]
  • (6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol[German][ACD/IUPAC Name]
  • (6aR,10aR)-6,6,9-Triméthyl-3-pentyl-6a,7,8,10a-tétrahydro-6H-benzo[c]chromén-1-ol[French][ACD/IUPAC Name]
  • 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-
  • 6H-Dibenzo[b,d]pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR,10aR)-[ACD/Index Name]
  • 6H-Dibenzo[b,d]pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-
  • Dronabinolum[Latin]
  • Marinol[Trade name]
  • Marinol (TN)
  • MFCD00083207[MDL number]
  • δ(9)-Tetrahydrocannabinol
  • δ1-Tetrahydrocannabinol
  • δ1-THC
  • δ-9-TETRAHYDROCANNABINOL
  • δ9-THC
  • δ9-THC
  • (-)- δ 9-Tetrahydrocannabinol
  • (-)-(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
  • (-)-3,4-trans-δ1-Tetrahydrocannabinol
  • (-)-trans-δ 1-Tetrahydrocannabinol
  • (-)-trans-δ 9-Tetrahydrocannabinol
  • (-)-trans-δ 9-THC
  • (-)-trans-δ1-Tetrahydrocannabinol
  • (-)-trans-δ9-Tetrahydrocannabinol
  • (-)-δ 1-Tetrahydrocannabinol
  • (-)-δ 9-THC
  • (-)-δ 9-trans-Tetrahydrocannabinol
  • (-)-δ(sup 1)-3,4-trans-Tetrahydrocannabinol
  • (-)-δ(sup9)-trans-Tetrahydrocannabinol
  • (-)-δ1-Tetrahydrocannabinol
  • (-)-δ1-Tetrahydrocannabinol
  • (-)-δ9-(trans)-Tetrahydrocannabinol
  • (10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
  • (6aR,10aR)-3-amyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol
  • (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol
  • (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol
  • (6aR,10aR)-6a,7,8,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo(b,d)pyran-1-ol
  • (6aR,10aR)-6a,7,8,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol
  • (6aR-trans)-6a,7,8,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo(b,d)pyran-1-ol
  • (L)-δ 1-Tetrahydrocannabinol
  • (l)-δ(sup 1)-Tetrahydrocannabinol
  • (l)-δ1-Tetrahydrocannabinol
  • (L)-δ1-Tetrahydrocannabinol
  • 1-trans-δ 9-Tetrahydrocannabinol
  • 1-trans-δ(sup 9)-Tetrahydrocannabinol
  • 1-trans-δ(sup9)-tetrahydrocannabinol
  • 1-trans-δ(sup9)-tetrahydrocannabinol
  • 1-trans-δ9-Tetrahydrocannabinol
  • 1-TRANS-δ-9-TETRAHYDROCANNABINOL
  • 3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,d)pyran-1-ol
  • 6,6,9-Trimethyl-3-pentyl-7,8,9,10-tetrahydro-6H-dibenzo(b,d)pyran-1-ol
  • 6,6,9-Trimethyl-3-pentyl-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyran-1-ol
  • 6aR,7,8,10aR-tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol
  • 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR,10aR)-
  • 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, trans-
  • 6H-Dibenzo[b, d]pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-
  • 6H-Dibenzo[b, d]pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-
  • 6H-Dibenzo[b, d]pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, trans-
  • 6H-Dibenzo[b,d]pyran-1-ol, 6a,7,8, 10a-tetrahydro-6,6,9-trimethyl-3-pentyl-
  • 6H-Dibenzo[b,d]pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6, 9-trimethyl-3-pentyl-, (6aR-trans)-
  • 6H-Dibenzo[b,d]pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, trans-
  • Cannabinol, 1-trans-δ(sup 9)-tetrahydro-
  • Cannabinol, 1-trans-δ(sup9)-tetrahydro-
  • Cannabinol, δ1-tetrahydro-
  • Cannabinol, δ1-tetrahydro-
  • Deltanyne
  • Exocyclic δ (9)(11)-Tetrahydrocannabiol
  • Δ9-THC
  • Δ9-THC (CRM)
  • L-trans-δ 9-Tetrahydrocannabinol
  • L-trans-δ9-Tetrahydrocannabinol
  • L-trans-δ9-Tetrahydrocannabinol
  • L-δ 1-trans-Tetrahydrocannabinol
  • L-δ1-Tetrahydrocannabinol
  • l-δ1-trans-Tetrahydrocannabinol
  • L-δ1-trans-Tetrahydrocannabinol
  • Marinol®
  • Maxepa
  • Primolut
  • Syndros
  • Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo(b,d)pyran-1-ol
  • Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol
  • Tetrahydrocannabinol δ9
  • Tetranabinex
  • THC
  • trans-6a,7,8,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo(b,d)pyran-1-ol
  • trans-δ (-)-9-Tetrahydrocannabinol
  • trans-δ 9-Tetrahydrocannabinol
  • trans-δ9-Tetrahydrocannabinol
  • trans-δ9-Tetrahydrocannabinol
  • δ 1-Tetrahydrocannabinol
  • δ 1-THC
  • δ 9-Tetrahydrocannabinol
  • δ 9-THC
  • δ 9-trans-Tetrahydrocannabinol
  • δ(1)-Tetrahydrocannabinol
  • δ(9)-Tetrahydrocannibinol
  • δ(9)-THC
  • δ(sup 1)-Tetrahydrocannabinol
  • δ(sup 1)-thc
  • δ(sup 9)-tetrahydrocannabinol
  • δ(sup 9)-thc
  • δ(sup9)-THC
  • δ1-Tetrahydrocannabinol
  • δ1-Tetrahydrocannabinol (VAN)
  • δ1-THC
  • δ9-Tetrahydrocannabinol
  • δ9-Tetrahydrocannabinol
  • Δ9-tetrahydrocannabinol
  • δ9-Tetrahydrocannabinol (VAN)
  • δ-9-THC
  • δ-9-THC
  • Δ9-THC
  • δ9-trans-Tetrahydrocannabinol
  • δ9-trans-Tetrahydrocannabinol

A common and widely used psychoactive plant, which is beginning to enjoy legal status for medical and even recreational use in some parts of the world. Usually smoked or eaten, primary effects are relaxation and an affinity towards food - a state described as being ‘stoned.’

Summary

The principal psychoactive constituent of cannabis is tetrahydrocannabinol (THC), which makes up one of 483 known compounds in the plant, including at least 84 other cannabinoids such as cannabidiol (CBD), cannabinol (CBN), tetrahydrocannabivarin (THCV), and cannabigerol (CBG). The genus cannabis is indigenous to central Asia and the Indian subcontinent. The earliest recorded uses of cannabis date from the 3rd millennium BC.

At least three species are recognized: Cannabis sativa, Cannabis indica, and Cannabis ruderalis. In modern times, cannabis is used for recreational or medicinal and religious or spiritual purposes. Since the early 20th century, cannabis has been subject to legal restrictions with the possession, use, and sale of cannabis preparations containing psychoactive cannabinoids currently illegal in most countries.

However, there is a recent growing trend towards decriminalization and legalization and the plant is legal in some states and countries such as Amsterdam. According to a United Nations report, cannabis is the most used illicit drug in the world. In 2004, the U.

N. estimated that global consumption patterns of cannabis indicated that approximately 4% of the adult world population (162 million people) used cannabis annually and that approximately 0. 6% (22.

5 million) of people used cannabis daily.

History

Tombs in China reveal humans were smoking cannabis 2500 years ago. The potency of illicit cannabis plant material has consistently increased over time since 1995 from ~4% in 1995 to ~12% in 2014. The cannabidiol content has decreased on average from ~.28% in 2001 to <.15% in 2014, resulting in a change in the ratio of Δ9-tetrahydrocannabinol to cannabidiol from 14 times in 1995 to ~80 times in 2014.

Chemistry

Cannabis contains more than 460 compounds; at least 80 of these are cannabinoids, chemical compounds that interact with cannabinoid receptors in the brain.

The most common cannabinoids are listed below:

Common Name(-)-.DELTA.9-trans-Tetrahydrocannabinol
Systematic name(-)-δ9-trans-Tetrahydrocannabinol
FormulaC_{21}H_{30}O_{2}
SMILESCCCCCc1cc(c2c(c1)OC([C@H]3[C@H]2C=C(CC3)C)(C)C)O
Std. InChi
Std. InChiKey
Avg. Mass314.4617 Da
Molecular Weight314.4617
Monoisotopic Mass314.224579 Da
Nominal Mass314
ChemSpider ID15266

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Dose Chart

Smoked
Light10-20mg
Common20-60mg
Strong60-100mg+

Duration Chart

Smoked
Onset1-10 minutes
Duration1-4 hours
After-effects2-24 hours

Interactions

Caution

  1. Mushrooms
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  2. LSD
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  3. DMT
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  4. Mescaline
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  5. DOx
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  6. NBOMes
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. 2C-x
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  8. 2C-T-x
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  9. αMT
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Small amounts can reduce nausea with aMT but take care.
  10. 5-MeO-xxT
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  11. Amphetamines
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  12. Cocaine
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

Dangerous

    Low Synergy

    1. Benzodiazepines

    No Synergy

    1. Caffeine
    2. SSRIs

    High Synergy

    1. Ketamine
    2. MXE
    3. DXM
    4. PCP
    5. N2O
    6. MDMA
      • Large amounts of cannabis may cause strong and somewhat unpredictable experiences in combination with MDMA. Cannabis should be saved for towards the end of the experience if possible.
    7. Alcohol
      • In excess, this combination can cause nausea.
    8. GHB/GBL
    9. Opioids
    10. Tramadol
    11. MAOIs

    Legal Status

    The legality of cannabis for medical and recreational use varies by country, in terms of its possession, distribution, and cultivation, and (in regards to medical) how it can be consumed and what medical conditions it can be used for. These policies in most countries are regulated by the United Nations Single Convention on Narcotic Drugs that was ratified in 1961, along with the 1971 Convention on Psychotropic Substances and the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances. The World Health Organization (WHO) is calling for whole-plant marijuana, as well as cannabis resin, to be removed from Schedule IV—the most restrictive category of a 1961 drug convention signed by countries from around the world.

  1. Responsible use
  2. Hallucinogens
  3. Cannabinoids
  4. Synthetic cannabinoids
  5. Sources

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    3. PubChem National Center for Bio Informatics
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