Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is an Experimental Substance with little data. This is most likely because the substance is is not very old. Information is limite and incomplete.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

Read the full disclaimer here.

Description

ALD-52 Also known as:

  • (8β)-1-Acetyl-N,N-diethyl-6-methyl-9,10-didehydroergolin-8-carboxamid[German][ACD/IUPAC Name]
  • (8β)-1-Acetyl-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide[ACD/IUPAC Name]
  • (8β)-1-Acétyl-N,N-diéthyl-6-méthyl-9,10-didéhydroergoline-8-carboxamide[French][ACD/IUPAC Name]
  • 1-ACETYLLYSERGIC ACID DIETHYLAMIDE
  • Ergoline-8-carboxamide, 1-acetyl-9,10-didehydro-N,N-diethyl-6-methyl-, (8β)-
  • Ergoline-8-carboxamide, 1-acetyl-9,10-didehydro-N,N-diethyl-6-methyl-, (8β)-[ACD/Index Name]
  • Ergoline-8β-carboxamide, 1-acetyl-9,10-didehydro-N,N-diethyl-6-methyl-
  • (+)-Lysergic acid acetyldiethylamide
  • [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-(4-methoxyphenyl)acetate
  • 08/02/3270
  • 4-25-00-00972 (Beilstein Handbook Reference)[Beilstein]
  • D-1-Acetyl lysergic acid diethylamide
  • Ergoline-8-carboxamide, 1-acetyl-9,10-didehydro-N,N-diethyl-6-methyl-, (8-β)-
  • Lysergamide, 1-acetyl-N,N-diethyl- (6CI,7CI)

ALD-52, or N-acetyl-LSD is a less common chemical analogue of LSD, first synthesised by Albert Hoffman. It was famously implicated in the ‘Orange Sunshine’ trial. A psychedelic lysergamide, this compound exhibits similar properties to LSD, and is thought to be a pro-drug for LSD.

Summary

It is structurally related to psychedelic lysergamides like LSD and 1P-LSD and is reported to produce largely indistinguishable effects. ALD-52 was originally discovered by in his study of LSD analogs, but it did not enter mainstream awareness until the 1960s Western youth counterculture. ALD-52 gained public notoriety when it was supposedly distributed as LSD in the 1960s under the now-famous name "Orange Sunshine.

" This was later disproven (see section below). Alexander Shulgin touches briefly on the subject of ALD-52 in the commentary section of LSD-25 in the book TiHKAL (“Tryptamines I have Known and Loved”). His writings are based on second-hand accounts which state that doses in the 50-175 µg range result in various effects that are not particularly distinct from LSD.

His reports indicate that it produces less visual distortion than with LSD as well as less anxiety and tenseness, while also being somewhat less potent than LSD. Another report found the two substances to be indistinguishable. As with LSD itself, ALD-52 does not meet the criteria to be considered addictive or toxic by the scientific community.

Nevertheless, unpredictable adverse reactions such as anxiety, paranoia, delusions and psychosis are always possible, particularly among those who are predisposed to psychiatric disorders. While these negative reactions or “bad trips” can often be attributed to factors like user inexperience or improper preparation of set and setting, they are known to happen spontaneously among even highly experienced users as well. It is highly advised to approach this very potent, long-lasting hallucinogenic substance with the proper amount of preparation, and harm reduction practices if using it.

History

In 1968 and 1969, a famous batch of LSD known as "Orange Sunshine" was synthesized by Nick Sands and Tim Scully and made widely available in California. This "Orange Sunshine" was long held by the hippie generation to be ALD-52 until 2005, when it was revealed by Nick Sands that "Orange Sunshine" was just a particularly well made batch of LSD dosed at 300 micrograms per unit. This was confirmed by Tim Scully in a 2017 Reddit AMA, where Scully explained that the claim that "Orange Sunshine" was technically not LSD arose from an "ill-advised desperate defense strategy that failed miserably" during his trial for LSD manufacture.

Chemistry

ALD-52 is a substituted derivative of lysergic acid.

ALD-52’s structure contains four rings, a bicyclic hexahydroindole fused to a bicyclic quinoline group.

This core structure of ALD-52 is an ergoline derivative, and has tryptamine and phenethylamine structures embedded within it.

ALD-52 contains a N,N-diethylcarboxamide functional group bound to R8 of the chemical structure.

It is additionally substituted at carbon 6 with a methyl group. ALD-52 is homologous to 1P-LSD, which contains a propionyl group bound to CH3CO- instead of the acetyl group bound to the same location.

It is unknown how these differences account for differences in the two compound’s activity.

Common Name1-ACETYLLYSERGIC ACID DIETHYLAMIDE
Systematic name1-ACETYLLYSERGIC ACID DIETHYLAMIDE
FormulaC_{22}H_{27}N_{3}O_{2}
SMILESCCN(CC)C(=O)[C@H]1CN([C@@H]2Cc3cn(c4c3c(ccc4)C2=C1)C(=O)C)C
Std. InChiInChI=1S/C22H27N3O2/c1-5-24(6-2)22(27)16-10-18-17-8-7-9-19-21(17)15(13-25(19)14(3)26)11-20(18)23(4)12-16/h7-10,13,16,20H,5-6,11-12H2,1-4H3/t16-,20-/m1/s1
Std. InChiKeyFJOWXGYLIWJFCH-OXQOHEQNSA-N
Avg. Mass365.4687 Da
Molecular Weight365.4687
Monoisotopic Mass365.210327 Da
Nominal Mass365
ChemSpider ID174121

Become an Exclusive Member For Free

Become a member now, sign up, and get free updates, news articles, and the latest happenings in the Psychedelic World.

Dose Chart

Oral
Light25-75ug
Common75-150ug
Strong150-300ug.

Duration Chart

ALD-52 Duration Data
Onset45-90 minutes
Duration9-14 hours
After-effects12-24h

Legal Status

ALD-52 is currently a gray area compound within many parts of the world. This means that it is not known to be specifically illegal within most countries, but people may still be charged for its possession under certain circumstances such as under analog laws and with the intent to sell or consume.

  • Austria: ALD-52 is technically not illegal but it may fall in the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich) as an analogue of LSD.

  • Denmark: ALD-52 is not listed as an illegal substance in Denmark, and its chemical class 'lysergamide' is not banned under the Analogue Act (Some LSD analogues are, however, prohibited).
  • Germany: ALD-52 is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
  • Latvia: ALD-52 is illegal in Latvia. Although it isn't officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.
  • Poland: ALD-52 is a NPS class drug in Poland, making it illegal to possess or distribute.
  • United Kingdom: As of January 7, 2015, ALD-52 is specifically named in the U.K. Misuse of Drugs Act as a Class A controlled substance..
  • United States: ALD-52 is unscheduled in the United States. It may be considered an analogue of LSD, a Schedule I controlled substanceunder the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or scientific research could be prosecuted as crimes under the Federal Analogue Act.

    • Sources

    References

    1. Shulgin, Alexander; Shulgin, Ann (1997). "#26. LSD-25". TiHKAL: The Continuation. United States: Transform Press.  0-9630096-9-9. OCLC 38503252.
    2. Lüscher, Christian; Ungless, Mark A. (2006). "The Mechanistic Classification of Addictive Drugs". PLOS Medicine. 3 (11). :10.1371/journal.pmed.0030437.  1549-1277. PMID 17105338.
    3. Nichols, David E. (2016). Barker, Eric L., ed. "Psychedelics". Pharmacological Reviews. 68 (2): 264–355. :10.1124/pr.115.011478.  0031-6997.
    4. Strassmann, Rick (1984). "Adverse reactions to psychedelic drugs. A review of the literature". Journal of Nervous and Mental Disease. 172 (10): 577–595. :10.1097/00005053-198410000-00001.  0022-3018. OCLC 1754691. PMID 6384428.
    5. "Earth"; "Jon Hanna"; "Spoon" (March 14, 2016). "Ask Erowid : ID 3189 : Was Orange Sunshine actually ALD-52?". Erowid. Retrieved January 1, 2020.
    6. Armstrong, B. D.; Paik, E.; Chhith, S.; Lelievre, V.; Waschek, J. A.; Howard, S. G. (2004). "Potentiation of (DL)‐3,4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptior partial agonist d‐lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939". Neuroscience Research Communications. 35 (2): 83–95. :10.1002/nrc.20023.  1520-6769.
    7. Gudelsky, Gary A.; Yamamoto, Bryan; Nash, J. Frank (1994). "Potentiation of 3,4-methylenedioxymethamphetamine-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists". European Journal of Pharmacology. 264 (3): 325–330. :10.1016/0014-2999(94)90669-6.  0014-2999.
    8. Capela, J. P.; Fernandes, E.; Remião, F.; Bastos, M. L.; Meisel, A.; Carvalho, F. (2007). "Ecstasy induces apoptosis via 5-HT2A-receptor stimulation in cortical neurons". Neurotoxicology. 28 (4): 868–875. :10.1016/j.neuro.2007.04.005.  0161-813X. PMID 17572501.
    9. Passie, T.; Halpern, J. H.; Stichtenoth, D. O.; Emrich, H. M.; Hintzen, A. "The Pharmacology of Lysergic Acid Diethylamide: A Review" (PDF). CNS Neuroscience & Therapeutics. 14: 295–314. :10.1111/j.1755-5949.2008.00059.x.  1755-5930. Archived from the original (PDF) on May 1, 2013. Retrieved January 1, 2020.
    10. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
    11. "Samlet liste over euforiserende stoffer opført på bilag 1 til bekendtgørelsen om euforiserende stoffer nr. 557 af 31. maj 2011 og stoffer reguleret herefter via ændringsbekendtgørelser" (in Danish). Lægemiddelstyrelsen [Danish Medicines Agency]. June 13, 2018. Retrieved January 1, 2020.
    12. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
    13. "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF). Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27 (in German). Bundesanzeiger Verlag. July 17, 2019. pp. 1083–1094. Retrieved January 1, 2020.
    14. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
    15. "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" (in Latvian). VSIA Latvijas Vēstnesis. November 10, 2005. Retrieved January 1, 2020.
    16. "Rozporządzenie Ministra zdrowia z dnia 21 sierpnia 2019 r. zmieniające rozporządzenie w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych" (PDF) (in Polish).
    17. Advisory Council on the Misuse of Drugs (June 10, 2014). "Update of the generic definition for tryptamines" (PDF). Government Digital Service. p. 12. Retrieved January 1, 2020.

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.