Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

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Description

5-MeO-DMT Also known as:

  • 5-Methoxydimethyltryptamine
  • 1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl-[ACD/Index Name]
  • 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamin[German][ACD/IUPAC Name]
  • 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamine[ACD/IUPAC Name]
  • 2-(5-Méthoxy-1H-indol-3-yl)-N,N-diméthyléthanamine[French][ACD/IUPAC Name]
  • 3-(2-dimethylaminoethyl)-5-methoxyindole
  • 3-[2-(Dimethylamino)ethyl]-5-methoxyindole
  • 5-Methoxy-DMT
  • 5-methoxyindole 3-(2-(N,N-Dimethylamino)ethyl)
  • 5-methoxy-N,N-dimethyl-1H-indole-3-ethanamine
  • 5-methoxy-N,N-dimethyl-1H-indole-3-ethylamine
  • 5-Methoxy-N,N-Dimethyltryptamine
  • Indole, 3-(2-(N,N-dimethylamino)ethyl)-5-methoxy-
  • Indole, 3-[2- (dimethylamino)ethyl]-5-methoxy-
  • MFCD00005658[MDL number]
  • N,N-Dimethyl-5-methoxy tryptamine
  • N,N-Dimethyl-5-methoxytryptamine
  • N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N,N-dimethylamine
  • Bufotenine, 5-Methoxydimethyltryptamine
  • [1019-45-0]
  • [2-(5-methoxy-1H-indol-3-yl)ethyl]dimethylamine
  • [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-dimethyl-amine
  • [2-(5-methoxyindol-3-yl)ethyl]dimethylamine
  • 2-(5-methoxy-1H-indol-3-yl)ethyl-dimethyl-amine
  • 2-(5-methoxy-1H-indol-3-yl)ethyl-dimethylammonium
  • 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethan-1-amine
  • 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamine
  • 2-(5-methoxy-1H-indole-3-yl)-N,N-dimethylethanamine[ACD/IUPAC Name]
  • 3-(2-(N,N-Dimethyl)aminoethyl)-5-methoxyindole
  • 3-(2-(N,N-Dimethylamino)ethyl)-5-methoxyindole
  • 3-[2-(N,N-Dimethylamino)ethyl]-5-methoxyindole
  • 3-[2-(N,N-Dimethylamino)ethyl]-5-methoxy-indole
  • 5-methoxy DMT
  • 5-methoxy-3-N,N-dissopropylamino-ethylindole
  • Bufotenine, O-methyl-
  • cid_1832
  • Indole, 3-(2-(dimethylamino)ethyl)-5-methoxy-
  • Indole, 3-(2-(N,N-dimethylamino)ethyl)-5-methoxy
  • Indole, 3-[2-(dimethylamino)ethyl]-5-methoxy-
  • Indole, 3-[2-(N,N-dimethylamino)ethyl]-5-methoxy-
  • MeODMT
  • methoxybufotenin
  • Methoxydimethyltryptamine
  • Methoxydimethyltryptamines
  • Methylbufotenine
  • N,N-Dimethyl-5-methoxytryptamine, free base
  • O-methylbufotenine
  • WLN: T56 BMJ D2N1&1 GO1

A powerful psychedelic tryptamine found in many species of plants and some toad venom, with a history of use by native South Americans spanning thousands of years. Has similar qualities to DMT and related tryptamines. Very potent. Orally active in combination with an MAOI.

Summary

As with its structural relatives DMT and 5-HO-DMT (Bufotenin), 5-MeO-DMT has been used as an entheogen by South American shamans for thousands of years and has recently been demonstrated to induce mystical experiences. It is distributed in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). It has also been shown to be produced endogenously in the human body in trace amounts, although its biological function is unclear.

In modern times, 5-MeO-DMT is primarily acquired and consumed in its synthetic powder form through the use of online research chemical vendors. When taken in its synthetic powder form, 5-MeO-DMT is typically vaporized, but can also be insufflated (although this is discouraged), and is active at a dose of as little as 2 mg. It has been suggested that it possesses roughly 4-5x the potency of DMT.

As with DMT, 5-MeO-DMT has been demonstrated to be active orally when taken with an MAOI, but according to numerous reports this combination tends to be extremely unpleasant, producing a strong body load in addition to the risk of hypertensive symptoms and serotonin syndrome, and is therefore strongly advised against. On both physical and psychological levels, it is considered to be substantially less safe than DMT. Anecdotal reports indicate that this substance is likely to be overly intense for those who are not already extensively experienced with hallucinogens, specifically powerful psychedelic tryptamines like DMT, ayahuasca and DPT.

Therefore it is highly advised to approach this very unpredictable, and powerful hallucinogenic substance with the proper amount of precaution, preparation, and harm reduction practices if one chooses to use it.

Chemistry

Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to a terminal amine group via an ethyl side chain.

5-MeO-DMT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−; it also contains two methyl groups CH3- bound to the terminal amine RN of its tryptamine backbone (DMT).

5-MeO-DMT is the N-substituted methyl homologue of 5-MeO-MiPT and 5-MeO-DiPT, although it radically differs in its effects.

Common Name5-Methoxydimethyltryptamine
Systematic name5-Methoxydimethyltryptamine
FormulaC_{13}H_{18}N_{2}O
SMILESCN(C)CCc1c[nH]c2c1cc(cc2)OC
Std. InChiInChI=1S/C13H18N2O/c1-15(2)7-6-10-9-14-13-5-4-11(16-3)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3
Std. InChiKeyZSTKHSQDNIGFLM-UHFFFAOYSA-N
Avg. Mass218.2948 Da
Molecular Weight218.2948
Monoisotopic Mass218.141907 Da
Nominal Mass218
ChemSpider ID1766

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Dose Chart

Smoked
Light2-5mg
Strong10-20mg
Insufflated
Light3-5mg
Common5-10mg
Strong8-15mg

Duration Chart

Smoked
Onset0-1 minutes
Duration5-15 minutes
After-effects1-2 hours

Interactions

Caution

  1. Mescaline
    • The 5-MeO class of tryptamines can be unpredictable in their interactions
  2. DOx
    • The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
  3. NBOMes
    • The 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMes are known to be unpredictable even alone. This combination is best avoided
  4. 2C-x
    • The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
  5. 2C-T-x
    • Both classes of compounds can be unpredictable alone
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. MDMA
    • Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care

Dangerous

  1. DXM
    • Little information exists about this combination.
  2. Amphetamines
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
  3. Cocaine
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
  4. Tramadol

Low Synergy

  1. Alcohol
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
  2. Opioids

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. MXE
    • Little information exists about this combination.
  5. Ketamine
  6. N2O

Legal Status

  • Austria: 5-Meo-DMT is, as an ether of N,N-DMT, illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
  • China: As of October 2015, 5-MeO-DMT is a controlled substance in China.
  • Denmark: As of December 2004, 5-MeO-DMT is legally restricted to "medical or scientific purposes".
  • Germany: 5-MeO-DMT is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of October 10, 2000. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Greece: 5-MeO-DMT became a controlled substance in Greece on February 18, 2003 [EU Legal Database].
  • Latvia: 5-MeO-DMT is a Schedule I drug.
  • New Zealand: 5-MeO-DMT is Schedule I (Class A) in New Zealand.
  • Romania: 5-MeO-DMT is illegal in Romania since February 2010.
  • Sweden: 5-MeO-DMT was classified as a health hazard under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated as the "Act on the Prohibition of Certain Goods Dangerous to Health") in their regulation SFS 2004:696, making it illegal to sell or possess as of Oct 1, 2004.
  • Switzerland: 5-MeO-DMT is Schedule I in Switzerland.
  • United Kingdom: 5-MeO-DMT is a Class A drug in the UK as it is an ether of the drug 5-HO-DMT, which is a Class A drug as a result of the tryptamine catch-all clause.
  • United States: 5-MeO-DMT was added to Schedule I, effective January 19, 2011. This means it is illegal to manufacture, buy, possess, or distribute (sell, trade or give) without a DEA license.

    • Sources

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    399. Springer Nature Activity of serotonin-containing nucleus centralis superior (raphe medianus) neurons in freely moving cats
    400. Springer Nature An ab initio SCF molecular orbital study on the conformation of serotonin and bufotenine
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    402. Springer Nature Anti-aversive role of serotonin in the dorsal periaqueductal grey matter
    403. Springer Nature Behavioral effects of ??,??,??,??-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor
    404. Springer Nature Behavioral effects of 5-methoxy-N,N-dimethyltryptamine and dose-dependent antagonism by BC-105
    405. Springer Nature Biological activities of some 5-substituted N,N-dimethyltryptamines, ??-methyltryptamines, and gramines
    406. Springer Nature Blockade of dopamine receptors explains the lack of 5-HT stereotypy on treatment with the putative 5-HT1A agonist LY165163
    407. Springer Nature Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions
    408. Springer Nature Changes in rat dopamine- and serotonin function in vivo after prolonged administration of the specific 5-HT uptake inhibitor, citalopram
    409. Springer Nature Choroid plexus epithelial cells in primary culture: a model of 5HT1C receptor activation by hallucinoginic drugs
    410. Springer Nature Circadian variation in behavioural responses to central 5-HT receptor stimulation in the mouse
    411. Springer Nature Comparison of the pharmacological characteristics of 5 HT1 and 5 HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release
    412. Springer Nature Die Isolierung von N-Methyltryptamin, 5-Methoxy-N-methyltryptamin und 5-Methoxy-N,N-dimethyltryptamin aus der Rinde von Piptadenia peregrina Benth
    413. Springer Nature Differential effects of 5-hydroxytryptamine antagonists on behaviors resulting from activation of different pathways arising from the raphe nuclei
    414. Springer Nature Differential effects of substance P on serotonin-modulated spinal nociceptive reflexes
    415. Springer Nature Discriminative stimulus properties of the serotonin agonist MK 212
    416. Springer Nature Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats
    417. Springer Nature Effect of chronic antidepressant treatment and subsequent withdrawal on [3H]-5-hydroxytryptamine and [3H]-spiperone binding in rat frontal cortex and serotonin receptor mediated behaviour
    418. Springer Nature Effect of isolation rearing on 5-HT agonist-induced responses in the rat
    419. Springer Nature Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors
    420. Springer Nature Effects of 5-hydroxytryptamine on the firing rates of neurons of the lateral vestibular nucleus in the rat
    421. Springer Nature Effects of the putative D-1 antagonist SCH 23390 on stereotyped behaviour induced by the D-2 agonist RU24213
    422. Springer Nature Elevation of brain GABA concentrations with amino-oxyacetic acid; effect on the hyperactivity syndrome produced by increased 5-hydroxytryptamine synthesis in rats
    423. Springer Nature Enhancement of 5-Hydroxytryptamine-induced behavioral effects following chronic administration of antidepressant drugs
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    425. Springer Nature Functional supersensitivity to adrenergic agonists in the rat after DSP-4, a selective noradrenergic neurotoxin
    426. Springer Nature Hallucinogen-induced rotational behavior in rats
    427. Springer Nature Hallucinogenic agents as discriminative stimuli: A correlation with serotonin receptor affinities
    428. Springer Nature Hyponeophagia and arousal in rats: Effects of diazepam, 5-methoxy-N,N-dimethyltryptamine, d-amphetamine and food deprivation
    429. Springer Nature Indolealkylamines: Biotransformations and Potential Drugu2013Drug Interactions
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    433. Springer Nature Involvement of dopamine in the antinociceptive response to footshock
    434. Springer Nature Involvement of noradrenaline in potentiation of the head-twitch response by GABA-related drugs
    435. Springer Nature Lack of prophylactic or therapeutic efficacy of 5-HT2A receptor antagonists in halothane-induced porcine malignant hyperthermia
    436. Springer Nature LDH isoenzyme spectrum in the myocardium of rats after repeated doses of isoproterenol
    437. Springer Nature Microdialysis study of effects of atypical neuroleptics and anxiolytics on striatal dopamine release and metabolism in conscious rats
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    439. Springer Nature Modulation of the vestibulo-ocular reflex by serotonin in the rat
    440. Springer Nature N-dimethylated indoleamines in blood of acute schizophrenics
    441. Springer Nature null
    442. Springer Nature Postmortem- and cryostability of the potassium-evoked release of [3H]5-hydroxytryptamine from rat cerebral cortical miniprisms
    443. Springer Nature Prevention of the serotonin syndrome in rats by repeated administration of monoamine oxidase inhibitors but not tricyclic antidepressants
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    445. Springer Nature Receptors for 5-hydroxytryptamine on the sympathetic nerves of the rabbit heart
    446. Springer Nature Serotonergic function in mouse head twitches induced by lithium and reserpine
    447. Springer Nature Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine
    448. Springer Nature Simultaneous determination of tryptamine analogues in designer drugs using gas chromatographyu2013mass spectrometry and liquid chromatographyu2013tandem mass spectrometry
    449. Springer Nature Stimulation of rat prolactin secretion by indolealkylamine hallucinogens
    450. Springer Nature Structure activity relations of some indolealkylamines in comparison to phenethylamines on motor activity and acquisition of avoidance behavior
    451. Springer Nature Subsensitivity of serotonin and substance P receptors involved in nociception after repeated administration of a serotonin receptor agonist
    452. Springer Nature Supersensitivity to l-5-hydroxytryptophan after 5,7-dihydroxytryptamine injections in desmethylimipramine- and nomifensine-pretreated rats: Behavioral evidence for postsynaptic supersensitivity
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    454. Springer Nature The influence of central noradrenergic function on 5-HT2-mediated head-twitch responses in mice: Possible implications for the actions of antidepressant drugs
    455. Springer Nature The inhibition of A and B forms of MAO in the production of a characteristic behavioural syndrome in rats after l-tryptophan loading
    456. Springer Nature The inhibition of the cage-leaving responseu2014A model for studies of the serotonergic neurotransmission in the rat
    457. Springer Nature The role of 5HT1A receptors in the modulation of the acoustic startle reflex in rats
    458. Springer Nature The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats
    459. Springer Nature Training dose as a factor in LSD-saline discrimination
    460. Thomson Pharma 00056720
    461. Tractus Company Limited
    462. Tractus Company Limited RT-004787
    463. Urine Metabolome Database HMDB0002004
    464. Vitas-M STK368074
    465. Wikidata Q570757
    466. Wikipedia 5-MeO-DMT
    467. Wonderchem WD04KBU
    468. Yuhao Chemical LQ1571
    469. ZINC ZINC00057152

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