Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

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Description

4-HO-DiPT Also known as:

  • 1H-Indol-4-ol, 3-[2-[bis(1-methylethyl)amino]ethyl]-[ACD/Index Name]
  • 3-[2-(Diisopropylamino)ethyl]-1H-indol-4-ol[ACD/IUPAC Name]
  • 3-[2-(Diisopropylamino)ethyl]-1H-indol-4-ol[German][ACD/IUPAC Name]
  • 3-[2-(Diisopropylamino)éthyl]-1H-indol-4-ol[French][ACD/IUPAC Name]
  • 4-HO-DiPT
  • 4-Hydroxy-di-isopropyl-tryptamine
  • 4-Hydroxy-N,N-Diisopropyltryptamine(4-OH-DIPT)
  • N,N-Diisopropyl-4-hydroxytryptamine
  • 3- {2- [di (propane-2-yl) amine] ethyl} -1 H-indole-4-ol[ACD/IUPAC Name]
  • 3-(2-(Diisopropylamino)ethyl)-1H-indol-4-ol
  • 3-(2-Aminoethyl)-N,N-diisopropyl-4-hydroxyindole
  • 3-[2-[di(propan-2-yl)amino]ethyl]-1H-indol-4-ol
  • 3-{2-[BIS(PROPAN-2-YL)AMINO]ETHYL}-1H-INDOL-4-OL
  • 3-{2-[Di(propan-2-yl)amino]ethyl}-1H-indol-4-ol
  • 4-Hydroxy-diisopropyltryptamine
  • 4-Hydroxy-di-isopropyl-tryptamine (4-HO-DiPT)
  • 4-Hydroxy-N,N-di(iso)propyltryptamine
  • 4-hydroxy-n,n-diisopropyltryptamine
  • 4-OH-DIPT
  • D-3890
  • MFCD04972059[MDL number]

A psychedelic tryptamine also known as iprocin. A homologue of psilocin, this drug likely has similar effects to psychedelic mushrooms. Said to have a rapid onset and relatively short duration for a drug of its class.

Summary

It is the 4-hydroxy analog of DiPT and is structurally related to tryptamines like 4-HO-DMT (Psilocin), 4-HO-MiPT (Miprocin), and 4-HO-DET (Ethocin). Following the publication of its synthesis by David B. Repke in 1977, its effects in humans were investigated by Alexander Shulgin.

It is characterized in his 1997 book TiHKAL (“Tryptamines I Have Known and Loved”) and is noted for being unique among psychedelics in terms of its speed (apparent 15 minutes after ingestion), intensity (20 milligrams can produce a transcendent peak experience), brevity (2-3 hours), and dose sensitivity. Additionally, idiosyncratic physical effects like muscle tremors and bodily malaise were noted. Today, 4-HO-DiPT is used for both recreational and entheogenic purposes.

It is relatively uncommon and occasionally distributed on the online research chemical market. Very little is known about the pharmacological properties, metabolism, and toxicity in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.

Chemistry

Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.

4-HO-DiPT is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−.

It also contains two isopropyl groups bound to the terminal amine RN of its tryptamine backbone. 4-HO-DiPT is a 4-hydroxy analog of DiPT and the N-substituted isopropyl homolog of 4-HO-DMT.

Common NameN,N-Diisopropyl-4-hydroxytryptamine
Systematic nameN,N-Diisopropyl-4-hydroxytryptamine
FormulaC_{16}H_{24}N_{2}O
SMILESCC(C)N(CCc1c[nH]c2c1c(ccc2)O)C(C)C
Std. InChiInChI=1S/C16H24N2O/c1-11(2)18(12(3)4)9-8-13-10-17-14-6-5-7-15(19)16(13)14/h5-7,10-12,17,19H,8-9H2,1-4H3
Std. InChiKeyKBRYKXCBGISXQV-UHFFFAOYSA-N
Avg. Mass260.3746 Da
Molecular Weight260.3746
Monoisotopic Mass260.188873 Da
Nominal Mass260
ChemSpider ID10579819

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Dose Chart

Oral
Threshold3-5mg
Light5-10mg
Common10-20mg
Strong20-30mg+

Duration Chart

4-HO-DiPT Duration Data
Onset20-60 minutes
Duration2-4 hours
After-effects1-6 hours

Legal Status

Due to its relative obscurity, the possession and sale of 4-HO-DiPT is unscheduled in most countries.

  • Germany: 4-HO-DiPT is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.

  • Sweden: 4-HO-DiPT is classified as a "health hazard" under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated to the "Act on the Prohibition of Certain Goods Dangerous to Health") as of March 1, 2005 in their regulation SFS 2005:26, making it illegal to sell or possess.
  • United Kingdom: 4-HO-DiPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.
  • United States: 4-HO-DiPT is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT), a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.
    • Florida: 4-HO-DiPT is a Schedule I controlled substance in the state of Florida, making it illegal to buy, sell, or possess.

    • Sources

    References

    1. https://www.erowid.org/library/books_online/tihkal/tihkal17.shtml Entry in TIHKAL
    2. Repke, DB; Ferguson, WJ; Bates, DK. Psilocin analogs. 1. Synthesis of 3-[2-(dialkylamino)ethyl]- and 3-[2-(cycloalkylamino)ethyl]indol-4-ols. J. Heterocycl. Chem., 1 Jan 1977, 14 (1), 71–74. 273 kB. http://dx.doi.org/10.1002/jhet.5570140113 | http://onlinelibrary.wiley.com/doi/10.1002/jhet.5570140113/abstract
    3. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p293 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf
    4. Shulgin, A., & Shulgin, A. (1991). IsomerDesign: "TiHKAL" - #17 - 4-HO-DiPT. Retrieved Jan 22, 2018.
    5. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
    6. "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    7. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    8. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    9. http://www.notisum.se/rnp/sls/sfs/20050026.pdf
    10. Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
    11. http://leg.state.fl.us/statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html

    Resources

    1. 1717 CheMall HE005945
    2. 1717 CheMall HE103447
    3. A&J Pharmtech AJ-38795
    4. AKos AKOS015914358
    5. Alfa Chemistry ACM132328451
    6. Alichem A199008348
    7. American Custom Chemicals Corp CHM0166072
    8. Angene AGN-PC-03goHT
    9. Ark Pharm, Inc. AK-30237
    10. Aurora Fine Chemicals A06.998.982
    11. Aurora Fine Chemicals K18.679.566
    12. BePharm B18030
    13. BGS International BG00318457
    14. BGS International BG04277733
    15. BGS International BG04596429
    16. Biosynth D-3890
    17. BLDpharm BD18030
    18. BOC Sciences 132328-45-1
    19. Boerchem BC220657
    20. Chembo Pharma KB-39205
    21. Chemenu CM148522
    22. ChemIDplus 132328451
    23. ChemIDplus 63065907
    24. Chemspace CSC000069546
    25. eMolecules 976869
    26. eNovation Chemicals K48908
    27. EPA DSSTox DTXCID90569590
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    29. FDA UNII - NLM YG9OUS518B
    30. Finetech Industry FT-0648658
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    44. Springer Nature Simultaneous determination of tryptamine analogues in designer drugs using gas chromatographyu2013mass spectrometry and liquid chromatographyu2013tandem mass spectrometry
    45. Wikidata Q229960
    46. Wikipedia 4-HO-DiPT

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

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