Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.

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Description

25I-NBOMe Also known as:

  • 2-(4-Iod-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine[ACD/IUPAC Name]
  • 2-(4-Iodo-2,5-diméthoxyphényl)-N-(2-méthoxybenzyl)éthanamine[French][ACD/IUPAC Name]
  • 2,5-DIMETHOXY-4-IODO-N-(2-METHOXYBENZYL)PHENETHYLAMINE
  • 25I-NBOMe
  • 547KGL06IP
  • Benzeneethanamine, 4-iodo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-[ACD/Index Name]
  • 2-(4-iodo-2,5-dimethoxy-phenyl)ethyl-(2-methoxybenzyl)amine
  • 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
  • 2-(4-iodo-2,5-dimethoxy-phenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
  • 2C-I-NBOMe
  • N-(2-methoxybenzyl)-2-(4-iodo-2,5-dimethoxyphenyl)ethanamine
  • NBOMe-2C-I
  • UNII:547KGL06IP
  • UNII-547KGL06IP

A relatively new and popular research chemical with psychedelic properties. Users report an uncomfortable body load with very strong visuals, though with less of a mental aspect than most psychedelics. Commonly mis-sold as LSD, since it is much cheaper to produce. Is considered quite unsafe, and has caused several deaths at ‘regular’ doses.

Summary

The name 25I-NBOMe, which short-hand for 2C-I-NBOMe, is a derivative of the phenethylamine psychedelic 2C-I. It was first synthesized and documented in 2003 by Ralf Heim at the Free University of Berlin. It was further researched by a team at Purdue University led by David Nichols.

It has been studied in its 11C radiolabelled form as a potential ligand for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography (PET). It is worth noting that compounds of the NBOMe family are not orally active and should be administered sublingually by placing and holding it into one’s mouth and allowing it to absorb over a period of 15-25 minutes. Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25I-NBOMe in humans.

It had no history of human use before being sold online as a designer drug in 2010. . It has been associated with many deaths and hospitalizations.

Anecdotal reports suggest that this substance may be difficult to use safely due to its highly sensitive dose-response and unpredictable effects.

Chemistry

25I-NBOMe is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 as well as an iodine atom attached to carbon R4.

It differs from 2C-I structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group.

25I-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family.

This NBOMe addition contains a methoxy ether CH3O- bound to a benzene ring at R2.

Common Name25I-NBOMe
Systematic name25I-NBOMe
FormulaC_{18}H_{22}INO_{3}
SMILESCOc1ccccc1CNCCc2cc(c(cc2OC)I)OC
Std. InChiInChI=1S/C18H22INO3/c1-21-16-7-5-4-6-14(16)12-20-9-8-13-10-18(23-3)15(19)11-17(13)22-2/h4-7,10-11,20H,8-9,12H2,1-3H3
Std. InChiKeyZFUOLNAKPBFDIJ-UHFFFAOYSA-N
Avg. Mass427.2767 Da
Molecular Weight427.2767
Monoisotopic Mass427.064423 Da
Nominal Mass427
ChemSpider ID8427392

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Dose Chart

Sublingual
Threshold50-250ug
Light200-500ug
Common500-750ug
Strong700-1000ug+

Duration Chart

25I-NBOMe Duration Data
Onset45-90 minutes
Duration5-10 hours
After-effects6-24 hours

Legal Status

  • Australia: Possession, production and sale is illegal.
  • Austria: Since June 26, 2019, 25I-NBOMe is illegal to possess, produce and sell under the SMG. (Suchtmittelgesetz Österreich)
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
  • Canada: 25I-NBOMe would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.
  • China: As of October 2015 25I-NBOMe is a controlled substance in China.
  • Denmark: 25I-NBOMe is controlled by the generic classification of phenethylamines in the Executive Order on Euphoriant Substances.
  • Germany: 25I-NBOMe is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of December 13, 2014. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Finland: 25I-NBOMe is controlled under the Medicines Act (395/87) as of March 15, 2013.
  • Hungary: 25I-NBOMe falls within the generic definition of phenethylamines in Schedule C of Government Decree 66/2012.
  • Israel: The drug was banned in 2012.
  • Italy: In Italy 25I-NBOMe is a Schedule 1 controlled substance, meaning it's illegal in this state.
  • Latvia: 25I-NBOMe is a Schedule I controlled substance.
  • New Zealand: 25I-NBOMe is a Schedule 2 controlled substance in New Zealand.
  • Norway: 25I-NBOMe is controlled by the generic scheduling of phenethylamines as of February 14, 2013.
  • Poland: 25I-NBOMe falls under the definition of a ‘substitution drug’ under the Act on Counteracting Drug Addiction and the Act on State Sanitary Inspection, 2010. As such its marketing and production is penalised with a fine (administrative sanctions).
  • Romania: In 2011, Romania banned all psychoactive substances, no matter what they really are.
  • Russia: Possession, production and sale is illegal.
  • Slovenia: 25I-NBOMe was included in a Decree amending the classification of illicit drugs (Official Gazette of RS No. 62/2013).
  • Sweden: 25I-NBOMe is classed as Schedule I.
  • United Kingdom: 25I-NBOMe is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.
  • United States: On Nov 15, 2013, the DEA added 25I-NBOMe to Schedule I using their emergency scheduling powers, making it "temporarily" in Schedule I for 2 years.

    • Sources

    References

    1. 25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
    2. "Fatalities / Deaths". Erowid. April 26 2013. Retrieved 7 May 2013. | http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
    3. 25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/nbome/nbome_death.shtml
    4. Ralf Heim PhD. (2010-02-28) "Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts." | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000001221 (in German). diss.fu-berlin.de. Retrieved 2013-05-10.
    5. Michael Robert Braden PhD. (2007). "Towards a biophysical understanding of hallucinogen action." | http://proquest.umi.com/pqdlink?Ver=1&Exp=01-23-2014&FMT=7&DID=1417800971&RQT=309&attempt=1&cfc=1 Purdue University. Retrieved 2012-08-08.
    6. https://www.ncbi.nlm.nih.gov/pubmed/21174090
    7. http://bitnest.ca/external.php?id=%18%3A3%172%1BE%24K%5BG%21%24%7D%04%04V
    8. Ettrup, A. E. A.; Hansen, M.; Santini, M. A.; Paine, J.; Gillings, N.; Palner, M.; Lehel, S.; Herth, M. M.; Madsen, J. (2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–693. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/21174090
    9. High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/18468904
    10. Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/21174090
    11. "Fatalities / Deaths". Erowid. April 26, 2013. Retrieved 7 May 2013. | http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
    12. http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome.shtml/
    13. "Kids overdosing on new drug. Laura Geller, WWBT NBC12, Feb 18, 2012 | http://www.nbc12.com/story/16964534/kids-overdosing-on-new-drug
    14. New street drug causing concern among medics. Vanessa Araiza, WBRC, Feb 28, 2012, | http://www.wsfa.com/story/16977573/new-street-drug-causing-concern-among-medics
    15. New drug N-bomb hits the street, terrifying parents, troubling cops | http://www.nydailynews.com/news/national/new-synthetic-hallucinogen-n-bomb-killing-users-cops-article-1.1336327
    16. Breaking Bad: Digital Drug Sales, Analog Drug Deaths. Craig Malisow, Houston Press, March 13, 2013 | http://www.houstonpress.com/2013-03-14/news/motion-research-charles-carlton/
    17. 21-year-old dies after one drop of new synthetic drug at Voodoo Fest. Naomi Martin, NOLA, November 1, 2012 | http://www.nola.com/crime/index.ssf/2012/11/21-year-old_dies_after_one_dro.html#incart_m-rpt-2/
    18. New hallucinogenic drug 25B-NBOMe and 25I-NBOMe led to South Australian man's bizarre death | http://www.adelaidenow.com.au/news/south-australia/new-hallucinogenic-drug-25b-nbome-and-25i-nbome-led-to-south-australian-mans-bizarre-death/story-e6frea83-1226472672220/
    19. https://erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
    20. https://erowid.org/chemicals/2cc_nbome/2cc_nbome_death.shtml
    21. https://erowid.org/chemicals/nbome/nbome_death.shtml
    22. https://onlinelibrary.wiley.com/doi/full/10.1002/dta.2751
    23. https://www.sciencedirect.com/science/article/abs/pii/S0033318218304882
    24. https://www.sciencedirect.com/science/article/abs/pii/S0378427418317533
    27. https://www.ris.bka.gv.at/Dokumente/BgblAuth/BGBLA_2019_II_167/BGBLA_2019_II_167.pdfsig
    28. http://portal.anvisa.gov.br/documents/10181/3115436/(1)RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
    29. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
    30. http://www.sfda.gov.cn/WS01/CL0056/130753.html | 关于印发《非药用类麻醉药品和精神药品列管办法》的通知
    31. "25I-NBOMe: EMCDDA–Europol Joint Report on a new psychoactive substance: 25I-NBOMe (4-iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine)" (PDF). European Monitoring Centre for Drugs and Drug Addiction. 2014. :10.2810/27828.  978-92-9168-682-7.  1977-7868. Retrieved February 18, 2020.
    32. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
    33. "Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 11, 2019.
    34. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
    35. http://www.health.gov.il/LegislationLibrary/25574413.pdf
    36. Tabella 1 Stupefacenti dello Stato Italiano |http://www.salute.gov.it/imgs/C_17_pagineAree_3729_listaFile_itemName_0_file.pdf
    37. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
    38. http://www.legislation.govt.nz/act/public/1975/0116/latest/whole.html#DLM436576
    39. http://drogriporter.hu/node/2211
    40. http://www.dreptonline.ro/legislatie/legea_194_2011_comba
    41. Läkemedelsverkets författningssamling - http://www.lakemedelsverket.se/upload/lvfs/LVFS_2013-15.pdf
    42. United Kingdom. (2014). Misuse of Drugs Act 1971 (S.I. 2014/1106). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/2014/1106/made
    43. http://www.justice.gov/dea/divisions/hq/2013/hq111513.shtml

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.