Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

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Description

25D-NBOMe Also known as:

  • 2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine[ACD/IUPAC Name]
  • 2-(2,5-Diméthoxy-4-méthylphényl)-N-(2-méthoxybenzyl)éthanamine[French][ACD/IUPAC Name]
  • 7RET11HE13
  • Benzeneethanamine, 2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-4-methyl-[ACD/Index Name]
  • NBOMe-2C-D
  • 2-(2,5-dimethoxy-4-methylphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
  • UNII:7RET11HE13

Uncommon analogue of 2C-D. Extremely potent psychedelic with stimulating qualities. Could cause dangerous vasoconstriction at high doses. May induce uncomfortable body load.

Summary

25D-NBOMe produces an array of primarily visual and stimulating psychedelic effects when administered. The name 25D-NBOMe, which short-hand for 2C-D-NBOMe, is a derivative of the phenethylamine psychedelic 2C-D. It was first synthesized in 2011 by Martin Hansen and subsequently had its activity explored in 2012 and 2014, where it was established to be a potent agonist at the 5-HT2A receptor that produces effects similar to other members of the 25x-NBOMe series.

It is worth noting that compounds of the NBOMe family are not orally active and should be administered sublingually by placing and letting it absorb into one’s mouth over a period of 15-25 minutes. 25D-NBOMe can also be vaporized and inhaled to cause significantly more rapid and powerful effects as well as a shorter duration. However, this route of administration is highly advised against due to the difficulties of measuring and handling substances that are both active in the microgram range as well as having a low therapeutic index.

25D-NBOMe has no history of human use prior to being sold online as a designer drug in 2010. Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25D-NBOMe in humans, and its closely related analogs like 25I-NBOMe has been associated with many deaths and hospitalizations. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely.

Therefore it is highly advised to approach this poorly understood psychedelic substance with the proper amount of precaution and harm reduction practices when using it.

Chemistry

25D-NBOMe is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 as well as a methyl group attached to carbon R4.

It differs from 2C-D structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image to the right.

25D-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family.

This NBOMe addition contains a methoxy ether CH3O- bound to a benzene ring at R2.

Common Name25D-NBOMe
Systematic name25D-NBOMe
FormulaC_{19}H_{25}NO_{3}
SMILESCc1cc(c(cc1OC)CCNCc2ccccc2OC)OC
Std. InChiInChI=1S/C19H25NO3/c1-14-11-19(23-4)15(12-18(14)22-3)9-10-20-13-16-7-5-6-8-17(16)21-2/h5-8,11-12,20H,9-10,13H2,1-4H3
Std. InChiKeyUTVHBNXCFSATDB-UHFFFAOYSA-N
Avg. Mass315.4067 Da
Molecular Weight315.4067
Monoisotopic Mass315.183441 Da
Nominal Mass315
ChemSpider ID48059920

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Dose Chart

Sublingual
Threshold100-300ug.
Light300-500ug.
Common500-1000ug
Strong1000-1250ug+

Duration Chart

25D-NBOMe Duration Data
Onset20-40 minutes
Duration4-6 hours
After-effects6-24 hours

Legal Status

Sources

References

  1. 25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
  2. 25C-NBOMe (2C-C-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2cc_nbome/2cc_nbome_death.shtml
  3. Other or Unknown NBOMe Compound Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/nbome/nbome_death.shtml
  4. 25I-NBOMe (2C-I-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
  5. 25C-NBOMe (2C-C-NBOMe) Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/2cc_nbome/2cc_nbome_death.shtml
  6. Other or Unknown NBOMe Compound Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/nbome/nbome_death.shtml
  7. Hansen, M. Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain. PhD Thesis, University of Copenhagen, 2011. | https://bitnest.netfirms.com/external.php?id=%18%3A3%172%1BE%24K%5BG%21%24%7D%04%04V
  8. Casale, John F.; Hays, Patrick A. (2012). "Characterization of Eleven 2,5-Dimethoxy-N-(2-methoxybenzyl)phenethylamine (NBOMe) Derivatives and Differentiation from their 3- and 4-Methoxybenzyl Analogues - Part I" (PDF). Microgram Journal. 9 (2): 84–109. Retrieved 14 January 2014.
  9. Hansen, M.; Phonekeo, K.; Paine, J. S.; Leth-Petersen, S.; Begtrup, M.; Bräuner-Osborne, H.; Kristensen, J. L. (2014). "Synthesis and Structure-Activity Relationships of N-Benzyl Phenethylamines as 5-HT2A/2C Agonists". ACS Chemical Neuroscience. 5 (3): 243–9. PMC 3963123 Freely accessible. PMID 24397362. https://doi.org/10.1021/cn400216u
  10. "Fatalities / Deaths". Erowid. April 26 2013. Retrieved 7 May 2013. | http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
  11. http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome.shtml/
  12. https://erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml
  13. https://erowid.org/chemicals/2cc_nbome/2cc_nbome_death.shtml
  14. https://erowid.org/chemicals/nbome/nbome_death.shtml
  15. https://onlinelibrary.wiley.com/doi/full/10.1002/dta.2751
  16. https://www.sciencedirect.com/science/article/abs/pii/S0033318218304882
  17. https://www.sciencedirect.com/science/article/abs/pii/S0378427418317533
  20. http://portal.anvisa.gov.br/documents/10181/3115436/(1)RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  21. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 11, 2019.
  22. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
  23. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
  24. Läkemedelsverkets författningssamling - http://www.lakemedelsverket.se/upload/lvfs/LVFS_2013-15.pdf
  25. United Kingdom. (2014). Misuse of Drugs Act 1971 (S.I. 2014/1106). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/2014/1106/made
  26. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
  27. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28

Information made possible with:

  1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
  2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
  3. PubChem National Center for Bio Informatics
  4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
  5. Wikipedia

Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

Data is constantly updated so please check back later to see if there is any more available information on this substance.