Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

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Description

1P-LSD Also known as:

  • (8β)-N,N-Diethyl-6-methyl-1-propionyl-9,10-didehydroergolin-8-carboxamid[German][ACD/IUPAC Name]
  • (8β)-N,N-Diethyl-6-methyl-1-propionyl-9,10-didehydroergoline-8-carboxamide[ACD/IUPAC Name]
  • (8β)-N,N-Diéthyl-6-méthyl-1-propionyl-9,10-didéhydroergoline-8-carboxamide[French][ACD/IUPAC Name]
  • 1-propionyl-lysergic acid diethylamide
  • 23R2G2G79C
  • Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-1-(1-oxopropyl)-, (8β)-[ACD/Index Name]
  • N,N-diethyl-6-methyl-1-propanoyl-9,10-didehydroergoline-8-carboxamide[ACD/IUPAC Name]
  • UNII:23R2G2G79C

An LSD analogue which appears to be slightly more potent with a shorter duration. Its effects are reported to be extremely similar to LSD, and thus far seems to be similarly safe. Released in late 2014, It has quickly become a highly popular research chemical due to its implicit legality, similarity to LSD and wide availability on the Internet.

Summary

1P-LSD is closely related to LSD and is reported to produce near-identical effects. Little is known about the pharmacology of 1P-LSD, but it likely produces its psychedelic effects by acting on serotonin receptors in the brain. The original synthesis date of 1P-LSD is unknown.

Unlike most research chemicals, 1P-LSD has no prior record in the scientific literature. The first reports of 1P-LSD use surfaced in 2015 following its appearance on the online research chemical market. It was marketed as a legal alternative to LSD alongside other novel lysergamides like ALD-52, ETH-LAD, and AL-LAD.

Subjective effects include geometric visual hallucinations, time distortion, enhanced introspection, conceptual thinking, euphoria, and ego loss. User reports indicate that the subjective effects of 1P-LSD are extremely similar to those of LSD. 1P-LSD is theorized to act as a prodrug for LSD.

This hypothesis is supported by the results of a study, showing 1P-LSD is metabolized to LSD in rats. This predicts a near-identical effect profile, likely differing mainly in its rate of absorption and duration. Characteristic effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss.

Its classical psychedelic effects and favorable tolerability has led it to become popular among novel psychoactive substance users who use it interchangeably with LSD. Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-LSD. It is presumed to have a similar toxicity and risk profile as LSD, although no evidence currently exists to support this.

It is highly advised to use harm reduction practices if using this substance.

History

A lucid argument can then be made that lysergic acid N,N-dimethylamide is derived from lysergic acid amide rather than LSD. Carrying this theme to the next logical step one would then assume that the 1-alkyl and 1-acyl derivatives of the N,N-dimethyl isomer would also not be controlled by the CsA amendment.— Donald A. Cooper, Future Synthetic Drugs of Abuse, 1988.

Chemistry

It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD.

Propionyl consists of the carbonyl chain CH3CH2CO- bound to an amino group. 1P-LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location.

The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group.

At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.

Common Name1P-LSD
Systematic name1P-LSD
FormulaC_{23}H_{29}N_{3}O_{2}
SMILESCCC(=O)n1cc2c3c1cccc3C4=C[C@H](CN([C@@H]4C2)C)C(=O)N(CC)CC
Std. InChiInChI=1S/C23H29N3O2/c1-5-21(27)26-14-15-12-20-18(17-9-8-10-19(26)22(15)17)11-16(13-24(20)4)23(28)25(6-2)7-3/h8-11,14,16,20H,5-7,12-13H2,1-4H3/t16-,20-/m1/s1
Std. InChiKeyJSMQOVGXBIDBIE-OXQOHEQNSA-N
Avg. Mass379.4953 Da
Molecular Weight379.4953
Monoisotopic Mass379.225983 Da
Nominal Mass379
ChemSpider ID52085129

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Dose Chart

Oral
Light25-50ug
Common50-125ug
Strong125-200ug

Duration Chart

1P-LSD Duration Data
Onset45-90 minutes
Duration8-12 hours
After-effects6-24 hours

Legal Status

1P-LSD is not scheduled under the UN Convention on Psychotropic Substances. It is considered to exist in a legal grey area in many countries, meaning that while it is not specifically illegal, individuals may still be charged for its possession under certain circumstances such as under analogue laws and with the intent to sell or consume.

  • Austria: 1P-LSD is technically not illegal but it may fall in the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich) as an analogue of LSD, thus making it illegal to supply for human consumption.

  • Canada: 1P-LSD is controlled as Schedule III substance under the Precursor Control Regulations of the Controlled Drugs and Substances Act.
  • Denmark: As of August 25, 2015, 1P-LSD is specifically named on the list of illegal substances.
  • Germany: 1P-LSD is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
  • Latvia: 1P-LSD is illegal in Latvia. Although it is not officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.
  • Lithuania: 1P-LSD is illegal in Lithuania and is specifically named on the list of illegal substances since September 21, 2015.
  • Sweden: Following its sale as a designer drug, 1P-LSD was made illegal in Sweden on January 26, 2016.
  • Switzerland: 1P-LSD is illegal in Switzerland as of December 2015.
  • Turkey: 1P-LSD is illegal in Turkey as of February 2016.
  • United Kingdom: 1P-LSD is illegal to produce, supply, or import under the Psychoactive Substance Act, which came into effect on May 26, 2016.
  • United States: Since 1P-LSD can be considered a prodrug for LSD, its possession and sale may be prosecutable in the United States under the Federal Analogue Act.

    • Sources

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    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
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